Is it possible to shrink the size of or eliminate fibroid uterine tumors through ANY means, such as diet, weight loss, acupuncture, etc.?

(Remember, in reading the answer - this question is about changing physical size of fibroids, not the relief of symptoms.)

2/23/99 


 

A: Unfortunately at this time, there is no diet, herbal or acupuncture treatment proven to decrease the size of uterine fibroids. But there are a few things that a patient might do for herself, and it seems primarily to involve weight control. What remains unclear, however, is how much of an effect all this has in the long run.

To begin with, overweight women tend to have more fibroids than women of normal weight. Athletic women have fewer fibroids than non-athletes. The common denominator may well be estrogen levels. To see how it may be related, let's examine the effect of estrogen on fibroid growth.


Generally speaking, Estrogen stimulates fibroid growth.
(Even this statement appears to have exceptions. No one ever said this subject was simple!!)

It is unlikely that estrogen triggers the change of a normal cell to a growing fibroid. It appears that fibroid tumors - like many other benign growths - may begin because there has been some sort of injury to a gene in a single cell. This so-called "mutation" causes the cell to lose control of its normal growth pattern, and by uncontrolled division the fibroid becomes increasingly larger. Estrogen probably exerts a stimulating effect only AFTER the fibroid develops.


Consider these facts about estrogen and fibroids:

  • Birth Control Pills: Estrogen is - of course - one of the two ingredients of the pill. From what has been said, it would appear logical that the pill will increase fibroid size. This has in fact been observed. However, it all becomes a bit confusing when one learns that there are studies which found that if "The Pill" was used BEFORE fibroids are detected, there appears to be a DECREASE in fibroid frequency! (Somehow timing must be important, but what this has to do with altering the incidence of mutation - if this is where it exerts an effect - is not worked out.)
  • Pregnancy: In pregnancy there is an extremely high estrogen environment. This causes pre-existing fibroids to enlarge 3-5 times their pre-pregnancy size. When the estrogen environment goes back to normal after pregnancy, most fibroids shrink back to near pre-pregnancy size! There may be some relation between this fact and the studies which suggest that women who have more pregnancies have fewer fibroids. What sort and how much of a protective effect pregnancy may give an individual woman - cannot be predicted.
  • Menopause: We have observed two opposite effects of Estrogen on fibroids during the menopause. (a) Fibroids may continue to increase in size, and pose a problem with the continuation of estrogen replacement (this is the most common scenario), or (b) Despite the use of estrogen, the fibroid size may remain unchanged. Why this happens and how to predict WHICH will happen - is unknown.
  • Greater Body Fat: Fat appears to increase estrogen levels. This may be why overweight women have more fibroids and less osteoporosis. Women who are very athletic tend to have lower body fat content, and - probably because of the Fat/Estrogen Connection - have fewer fibroids.
  • Pituitary Growth Hormone: A shadowy chemical from the pituitary may also be involved in fibroid growth. In other words, estrogen may have a partner in all this. The chemical in question is Growth Hormone. Women with fibroids tend to have higher levels of this chemical. Afro-American women have both higher Growth Hormone Levels than their Caucasian sisters, as well as a higher frequency of fibroids. Women with Diabetes have higher levels of Growth Hormone as well as a tendency to excess weight resulting in higher estrogen levels. Even if we knew ways to simply adjust the Growth Hormone Level, no one knows what sort of other side effects might result. The researchers are going to have to work this out first.

Bad Solutions to avoid: For instance, extreme exercise can result in such a drastic loss of estrogen that some women cease to menstruate. This is an unhealthy way to lower estrogen, and is not appropriate. Smoking is also correlated with fewer fibroids in some studies, but because of its correlation with lung and bladder cancer, and major cardiac and pulmonary disease - it too is a non-solution


Summary: If we are talking about changing fibroid size (as opposed to altering symptoms), there does not appear to be an Herbal, Vitamin or Acupuncture solution. Possibly (a) the early use of the birth control pill, (b) more pregnancies and (c) good weight control can lessen the frequency of fibroids somewhat. However - and this is the problem - it is not clear as to how effective any of these will be in an individual case. The data is "soft" at best.
 

 


 

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